


A research group from the UK found
that an increase in body mass may result in changes in heart shape,
specifically the shape of the heart’s left ventricle, with differences in
between gender. Tis article is written by Fanni R. Eros
Obesity
affects more than a third of the adult population and it is a leading cause of
preventable death. Obesity can cause adiposity that may, in the long run,
lead to cellular injury in the heart, left ventricular (LV) hypertrophy
(increased volume) and heart dysfunction. A wide variation in structural heart
adaptations has been observed in obesity, and gender-differences have also been
recognized. Cardiovascular magnetic resonance (CMR) offers accurate
quantitative assessment of heart geometry and of the structural changes caused
by obesity.
A
research group from the UK recently published their findings in the BMC
Journal of Cardiovascular Resonance. They investigated the relationship
between fat mass and left ventricle geometry. They assessed the structural
features of the left ventricle of the heart in 1530 adults between 2011 and
2015 with CMR and 3D analysis. The volunteers did not have any known cardiovascular disease, hypertension, diabetes or hypercholesterolemia. They found
that LV mass was weakly associated with fat mass in women, but not in men.
There was a relationship between fat mass and wall thickness (WT) in the whole
left ventricle in both sexes, however the relationship was stronger in men, and
women showed greater asymmetry. In addition, in men, increasing fat mass was
associated with reduction in endocardial volume (inner layer of the heart),
predominantly affecting the septal wall, while in women it was associated with
an increase in endocardial volume in basal and mid-ventricular levels.
Female
fat mass increase was also associated with a mild expansion of the epicardial
surface (the outer surface of the heart), which was confined to the septum and
lateral walls in males. Researchers found concentric hypertrophic pattern of
the left ventricle in men, while the hypertrophy was more asymmetric in women.
Furthermore, lean mass (that usually also increases in obesity) showed a strong
positive association with LV mass and WT for both genders, however, the
association was strongest in the cardiac septum area.
The study demonstrated that an increase in body mass may
result in changes in heart shape. These changes may lead to the development of
heart diseases later on, which could be prevented by reducing body mass.
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